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Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime.
Bellissimo CA, Delfinis LJ, Hughes MC, Turnbull PC, Gandhi S, DiBenedetto SN, Rahman FA, Tadi P, Amaral CA, Dehghani A, Cobley JN, Quadrilatero J, Schlattner U, Perry CGR. Bellissimo CA, et al. Among authors: delfinis lj. Am J Physiol Cell Physiol. 2023 May 1;324(5):C1141-C1157. doi: 10.1152/ajpcell.00377.2022. Epub 2023 Jan 23. Am J Physiol Cell Physiol. 2023. PMID: 36689672 Free article.
The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2.mdx mouse model of Duchenne muscular dystrophy.
Bellissimo CA, Gandhi S, Castellani LN, Murugathasan M, Delfinis LJ, Thuhan A, Garibotti MC, Seo Y, Rebalka IA, Hsu HH, Sweeney G, Hawke TJ, Abdul-Sater AA, Perry CGR. Bellissimo CA, et al. Among authors: delfinis lj. Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1011-C1026. doi: 10.1152/ajpcell.00638.2023. Epub 2023 Dec 25. Am J Physiol Cell Physiol. 2024. PMID: 38145301
Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia.
Delfinis LJ, Ogilvie LM, Khajehzadehshoushtar S, Gandhi S, Garibotti MC, Thuhan AK, Matuszewska K, Pereira M, Jones RG 3rd, Cheng AJ, Hawke TJ, Greene NP, Murach KA, Simpson JA, Petrik J, Perry CGR. Delfinis LJ, et al. bioRxiv [Preprint]. 2024 Apr 8:2024.04.08.588639. doi: 10.1101/2024.04.08.588639. bioRxiv. 2024. PMID: 38645227 Free PMC article. Preprint.
Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2 O2 emission during impaired oxidative phosphorylation.
Hughes MC, Ramos SV, Turnbull PC, Rebalka IA, Cao A, Monaco CMF, Varah NE, Edgett BA, Huber JS, Tadi P, Delfinis LJ, Schlattner U, Simpson JA, Hawke TJ, Perry CGR. Hughes MC, et al. Among authors: delfinis lj. J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):643-661. doi: 10.1002/jcsm.12405. Epub 2019 Apr 2. J Cachexia Sarcopenia Muscle. 2019. PMID: 30938481 Free PMC article.